Abstract of the Commemorative lecture
The Making of a Scientist
The power of gene targeting is that the investigator not only chooses which gene to modify, but also has virtually complete control over the way in which that gene's DNA sequence is altered. This technology permits the evaluation of the function of genes in an intact mammal and the systematic dissection of the most complex of biological processes such as development and learning. Because nearly all biological phenomena are mediated by genes, this technology will impact the analysis of all such phenomena in mammals, including the study of cancer, immunology, neurobiology and human congenital disease.
In this lecture, I describe our contribution to the development of this technology and recount a few persona experiences that may have influenced my own development as a scientist.
