The 1996 Laureates / Basic Sciences Category / Life Sciences (Molecular Biology, Cell Biology, Neurobiology)

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Mario Renato Capecchi

U.S.A. / October 6, 1937
Molecular Geneticist; Professor, The University of Utah

“Production of Knockout Mice through the Development of Gene Targeting Technique and Outstanding Contribution to Elucidation of Gene Function”
A molecular geneticist who developed the "gene targeting" technique, which is widely used around the world today. With his success in breeding mice in which targeted genes were inactivated, referred to as "knock-out" mice, Dr. Capecchi established a new avenue for researching how genes work. His method of research has benefited immensely such branches of life sciences as biology, medicine and agriculture.

BRIEF BIOGRAPHY

1937
Born in Verona, Italy
1961
B.S. Antioch College, U.S.A.
1967
Ph.D. Harvard University
1968
Assistant Professor, Harvard Medical School
1973
Professor of Biology, University of Utah
1988-present
Investigator of the Howard Hughes Medical Institute
1989-present
Professor of Human Genetics, School of Medicine, University of Utah

AWARDS AND HONORS

1969
American Chemical Society Awards in Biochemistry
1974
American Cancer Society Faculty Research Award
1986
Chairman of the Gordon Conference on Molecular Genetics
1991
Member of the National Academy of Sciences, U.S.A.
1993
Gairdner Foundation International Award for Achievements in Medical Sciences, Canada
1994
Sloan Prize, General Motors Cancer Research Foundation, U.S.A.

MAJOR WORKS

1980
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells. Cell, 22
1987
Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. (with K.R. Thomas) Cell, 51
1988
Disruption of the proto-oncogene int-2in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. (with S.L.Mansour and K.R. Thomas) Nature, 336
1991
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5 (with O. Chisaka) Nature, 350
1995
Absence of radius and ulna mice lacking hoxa-11 and hoxd-11. (with A.P. Davis, others) Nature, 375
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