The 2008 Laureates / Basic Sciences / Life Sciences (Molecular Biology, Cell Biology, Neurobiology)
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Anthony James Pawson

Canada, U.K. / October 18, 1952
Molecular Biologist
Distinguished Investigator, Samuel Lunenfeld Research Institute of Mount Sinai Hospital ; University Professor, University of Toronto

"Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction"
Dr. Pawson proposed and proved the concept that the unique adapter structure exists in signaling proteins, and that the binding of adapters to specific phosphotyrosine-containing domains induces cascades of intracellular signaling that controls cellular growth and differentiation. This concept has established one of the basic paradigms of signal transduction and significantly contributed to the subsequent development in life sciences.

BRIEF BIOGRAPHY
1952
Born in Maidstone, U.K.
1976
Ph.D. (Molecular Biology), London University
1976-1980
Postdoctoral Research Fellow, University of California, Berkeley
1981-1985
Assistant Professor, Department of Microbiology, The University of British Columbia
1985-2006
Senior Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
1985-1988
Associate Professor, Department of Medical Genetics and Microbiology, University of Toronto
1989-present
Full Professor, Department of Medical Genetics and Microbiology (now Department of Molecular Genetics), University of Toronto
1998-present
University Professor, University of Toronto
2000-2005
Director of Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital
2006-present
Distinguished Investigator, Samuel Lunenfeld Research Institute, Mount Sinai Hospital

SELECTED AWARDS AND HONORS
1994
International Award, Gairdner Foundation
2000
Officer of the Order of Canada
2005
Wolf Foundation Prize in Medicine, Wolf Foundation
2005
The Royal Medal, Royal Society of London
2006
Order of the Companions of Honour
Member:
Royal Society of London, Royal Society of Canada, National Academy of Sciences, American Academy of Arts and Sciences

SELECTED PUBLICATIONS
1984
Identification of functional regions in the transforming protein of Fujinami sarcoma virus by in-phase insertion mutagenesis (Stone, J. C., Atkinson, T., Smith, M. E. and Pawson, T.). Cell 37: 549-558.
1986
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps (Sadowski, I., Stone, J. C. and Pawson, T.). Molecular Cellular Biology 6: 4396-4408.
1990
Binding of SH2 domains of phospholipase Cγ1, GAP and Src to activated growth factor receptors (Anderson, D., Koch, C. A., Grey, L., Ellis, C., Moran, M. F. and Pawson, T.). Science 250: 979-982.
1990
Src homology region 2 domains direct protein-protein interactions in signal transduction (Moran, M., Koch, C. A., Anderson, D., Ellis, L., England, L., Martin, G. S. and Pawson, T.). Proceeding National Academy of Sciences, U.S.A. 87: 8622-8626.
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