The 2010 Laureates / Advanced Technology Category / Biotechnology and Medical Technology
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Shinya Yamanaka

Japan / September 4, 1962
Medical Scientist
Professor, Kyoto University

"Development of Technology for Generating Induced Pluripotent Stem (iPS) Cells"
By introducing just four transcription factor genes into dermal fibroblasts, Dr. Yamanaka succeeded in producing induced pluripotent stem (iPS) cells, which exhibit a pluripotency similar to that of embryonic stem (ES) cells. The iPS cell technology is now expected not only to expand the possibilities of regenerative medicine, but also to make significant contributions to the rapid progress of medical science in general.

BRIEF BIOGRAPHY
1962
Born in Osaka, Japan
1987
M.D., School of Medicine, Kobe University
1993
Ph.D. (Pharmacology), Graduate School of Medicine, Osaka City University
1993-1995
Postdoctoral Fellow, Gladstone Institute of Cardiovascular Disease
1999-2003
Associate Professor, Research and Education Center for Genetic Information, Nara Institute of Science and Technology
2003-2004
Professor, Research and Education Center for Genetic Information, Nara Institute of Science and Technology
2004-2010
Professor, Institute for Frontier Medical Sciences, Kyoto University
2007-present
Senior Investigator, Gladstone Institute of Cardiovascular Disease
2007-present
Professor, Institute for Integrated Cell-Material Sciences, Kyoto University
2008-2010
Director, Center for iPS Cell Research and Application, Institute for Integrated Cell-Material Sciences, Kyoto University
2010-present
Director, Center for iPS Cell Research and Application, Kyoto University

SELECTED AWARDS AND HONORS
2007
JSPS Prize, Japan Society for the Promotion of Science
2008
The Shaw Prize in Life Science and Medicine, The Shaw Prize Foundation
2008
Medal with Purple Ribbon (Japan)
2009
Canada Gairdner International Award, The Gairdner Foundation
2009
Albert Lasker Basic Medical Research Award, The Lasker Foundation
2010
March of Dimes Prize in Developmental Biology, The March of Dimes Foundation

SELECTED PUBLICATIONS
2003
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cell (Mitsui, K., Tokuzawa, Y., Itoh, H., Segawa, K., Murakami, M., Takahashi, K., Maruyama, M., Maeda, M. and Yamanaka, S.). Cell 113: 631-642.
2006
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors (Takahashi, K. and Yamanaka, S.). Cell 126: 663-676.
2007
Generation of germline-competent induced pluripotent stem cells (Okita, K., Ichisaka, T. and Yamanaka, S.). Nature 448: 313-317.
2007
Induction of pluripotent stem cells from adult human fibroblasts by defined factors (Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S.). Cell 131: 861-872.
2009
Suppression of induced pluripotent stem cell generation by the p53-p21 pathway (Hong, H., Takahashi, K., Ichisaka, T., Aoi, T., Kanagawa, O., Nakagawa, M., Okita, K. and Yamanaka, S.). Nature 460: 1132-1135.
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