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  3. Shuhei Nakamura

Shuhei Nakamura Shuhei Nakamura

Professor, Faculty of Medicine, Nara Medical University *Profile is at the time of the award.

2026TakameruBiology & Life sciences(takameru)

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Research topics
Molecular mechanisms of the lysosomal damage response and its role in aging.
Keyword
Summary
Lysosomes degrade intracellular and extracellular materials and also serve as hubs for signal transduction, thereby playing essential roles in maintaining cellular and organismal homeostasis. Lysosomal function declines with age, and this decline is thought to contribute to aging and the progression of age-related diseases, although the underlying mechanism remains unclear. In this study, we focus on the “lysosomal damage response,” which preserves lysosomal homeostasis by dealing with damaged lysosomes. Based on our hypothesis that disruption of this response contributes to lysosomal dysfunction and aging, we aim to clarify its molecular mechanisms and how this pathway is altered during aging, with the ultimate goal of providing a new framework for understanding and modulating aging.

Message

This project seeks to build on our long-standing research into the interplay between autophagy, lysosomes, and aging, and to uncover fundamental mechanisms underlying aging. In recent years, we have uncovered the molecular basis of multiple protective pathways that counteract damaged lysosomes, collectively termed the “lysosomal damage response,” as well as their links to aging. With support from this grant, we aim to define the overall framework of this response, determine how it is altered with age, and clarify how its disruption contributes to lysosomal dysfunction, aging, and the progression of age-related diseases. Through this work, we hope to provide new insights into the biology of aging and help move the field forward.

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Biology & Life sciences(takameru)

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