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Associate Professor, Department of Pharmacy, Gifu Pharmaceutical University *Profile is at the time of the award.
2024Inamori Research GrantsScience & Engineering
The realization of this research involves the generation of potent reducing chemical species through the utilization of inexpensive raw materials. While various powerful photoreducing agents have been developed to date, they typically possess expensive and complex frameworks. The present study aims to advance research towards the creation of reducing species equivalent to or surpassing those produced by existing metal-based one-electron reduction reactions.
In this study, we developed a new methodology based on the use of anionic species derived from organic molecules as powerful reductants and investigated the underlying reaction mechanisms. In particular, we focused on the ability of these organic anions to function as strong single-electron reductants under photoirradiation or appropriate reaction conditions, enabling challenging bond activation and radical-generation processes. We also demonstrated that the structure of the reductant can be rationally tuned to control its reducing ability, reactivity, and stability. These findings provide a new molecular design strategy for developing organic anion-based reductive transformations.
Yamaguchi, E., et al. (2025) Photocatalytic C–I Borylation via Halogen Bond-Enabled Electron Transfer: A Strategy for Generating Aryl Radicals from Haloarenes Chemical and Pharmaceutical Bulletin 73, 944-950 https://doi.org/10.1248/cpb.c25-00375
Science & Engineering
