Oisaki, Kounosuke

Lecturer, Graduate School of Pharmaceutical Sciences, The University of Tokyo *Profile is at the time of the award.

2021Inamori Research GrantsBiology & Life sciences

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Research topics: Iterative peptide synthesis using backbone protecting group-free amino acid

Keyword

Summary: Inverse iterative peptide synthesis that minimizes the waste will be pursued. Conventional peptide syntheses generate a large amount of waste derived from protecting groups and condensing agents, which is a problem in terms of cost and environmental friendliness. We will pursue a reaction pattern in which peptide thiocarboxylic acid conversion followed by main chain unprotected amino acid elongation is iteratively carried out, to establish a novel highly atom-economical peptide synthesis.

Comment

This project that we have been working on with students for several years is approaching the first goal. With the support of this grant, we hope to further accelerate and improve the quality of research.

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