Jumpei Taguchi

Project Assistant Professor, The Institute of Medical Science, The University of Tokyo*Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: BAC-based humanization with CRISPR-Cas9 ribonucleoprotein in mouse embryonic stem cells

Keyword

Summary: Mice have a genome that is 99% similar to humans and are useful model animals for diverse range of medical and life science researches. On the other hands, since there are some aspects that differ from humans, such as control mechanisms of gene expression and three-dimensional structure of proteins, it has been pointed out that there is a need for genomic humanization technology to replace target mouse gene locus with human gene locus. However, genomic humanization requires inducing recombination of a wide range of genomic regions, and versatile genomic humanization technology has not been established. In this research, we aim to develop full-length genomic humanization technology targeting genomic regions over 100kb by focusing on ES cells that has high homologous recombination efficiency.

Message

I'm great honored to receive generous support for my research as Inamori Research Grants. I would like to develop a versatile genomic humanization technology and contribute to advancement of medical and life science research.

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