Yoshiaki Abe

Assistant Professor, Institute of Medicine, University of Tsukuba *Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

Research topics: Exploring functions and clinical relevance of minor T-cell subsets in lymphoma

Summary: Lymphoma is a prevalent hematologic malignancy. In this study, we aim to investigate the biological and clinical significance of changes in follicular T cells in lymphomas, various solid cancers, and human lymph nodes, by conducting single-cell analysis in combination with functional experiments. We explore the potential for clinical and therapeutic applications.

Message

We will strive to achieve results that contribute to the improvement of understanding human lymphoma immunity.

Outline of Research Achievments

We performed a comprehensive analysis of tumor-infiltrating T cells in follicular lymphoma using single-cell RNA sequencing, in vitro functional assays, multiplex immunostaining (multiplex digital spatial profiling), spatial single-cell gene expression analysis, and clinical data (prognostic) analysis. Through these approaches, we identified minor T-cell populations within the tumor, characterized their gene expression profiles and anti-lymphoma activity, elucidated their mechanisms of action, explored their cellular origins and inducing factors, and established their prognostic significance.

Find other recipients

Biology & Life sciences

Ryohei Thomas Nakano

Hokkaido University

Masashi Mamada

Material Science

Tomoyuki Furuta

Okayama University

Ryo Fujimoto

Kobe University

Chikara Abe

Gifu University

Tomoko Okamoto

Kazunori Kume

Arisa Hirano

University of Tsukuba

Michihito Kono

Hiroshi Suzuki

Nagoya University

InaRIS Fellow

Dana Ulanova

Kochi University

Masaru Hojo

Kwansei Gakuin University

Kaori Sako

Tomonori Matsumoto

Biology & Life sciences Medicine

Akari Fujimoto

Shintaro Munemasa

Okayama University

Yuichi Yagita

Kyushu University

Tomoya Yamaguchi

Kumamoto University

Yoshihiro Ujihara

Nagoya Institute of Technology

Hirohisa Ohno

Kyoto University

Hiroshi Masai

Material Science

Takuma Kokusho

Junichi Kikuta

University of Tsukuba

Katsuyoshi Takaoka

Akiko Ogawa

Biology & Life sciences Life Science

Tomomi Koshiyama

Ritsumeikan University

Ayako Gotoh

Konan University

Takayuki Suzuki

Nagoya University

Takumi Suzuki

Ibaraki University

Taichi Noda

The University of Tokyo

Daisuke Takimoto

Material Science

Kana Furukawa

Osaka University

Akihiro Nishiguchi

National Institute for Materials Science

Akiko Kanehara

Kyoko Miura

Kumamoto University

Ryusuke Hatae

Kyushu University

Toshiro Moroishi

Satoshi Minami

Osaka University

Mitsuru Tsuge

Okayama University

Masahiko Saito

Material Science

Atsushi Saito

Sapporo Medical University

Hirofumi Toda

University of Tsukuba

Masakazu Hirota

Kenta Hirami

Noriyoshi Usui

Osaka University

Ritsuko Morita

Biology & Life sciences Life Science

Masayuki Sakamoto

Kumamoto University

Masayuki Tera

Tokyo University of Agriculture and Technology

Hidehisa Kawashima

University of Tsukuba

Mizuki Endo

Hitoshi Miyakawa

Utsunomiya University

Yu Miyamoto

Osaka University

Hideaki Morishita

Biology & Life sciences Life Science

Minako Ito

Yuichiro Mishima

Kyoto Sangyo University

Misuzu Hashimoto

Gifu University

Takaaki Ozawa

Osaka University

Toshiki Sawada

Material Science

Daisuke Ono

Biology & Life sciences Life Science

Miu Tamamitsu

The University of Tokyo

Takayuki Kuraishi

Kanazawa University

Tomonori Nakamura

Kyoto University

Rie Wakabayashi

Kyushu University

Yuma Takahashi

Nara Institute of Science and Technology

Teruhiko Imamura

Hironori Takeda

Hiroshima University

Hidenori Okamura

Tohoku University

Kotaro Mizuta

Kyoto University

Masafumi Kodama

Biology & Life sciences

Tomotaka Ishizaki

Nagoya University

Tsuyoshi Terakawa

Kyoto University

Yoshihiro Sakita

Kyogo Kobayashi

Kyushu University

Toyoaki Natsume

Research Organization of Information and Systems

Tomohiro Otsuka

Yu Fukasawa

Tohoku University

Kenichi Kimura

University of Tokyo

Shizue Ohsawa

Nagoya University

Yuki Honda

Material Science

Jumpei Taguchi

The University of Tokyo

Makoto Kobayashi

Shunsuke Tagami

RIKEN

Aiko Sada

Okayama University

Saori Morino-Koga

The University of Tokyo

Satoru Morimoto

Keio University

Masayuki Tsukasaki

The University of Tokyo

Hiroshi Nishimasu

The University of Tokyo

InaRIS Fellow

Shun Shibata

Tohoku University

Ryo Ichijo

Kyoto University

Satoshi Miura

Information Science

Masato Yamamichi

Research Organization of Information and Systems

Yoshiyuki Manabe

Tokai University

Shunsuke Kon

Tokyo University of Science

Hidenori Nishio

Nagoya City University

Kiyoharu Fukushima

Kyoto University

Tetsuya Kadonosono

Tokyo Institute of Technology

Yuta Hiraike

The University of Tokyo

Takashi Iwasaki

Tottori University

Azusa Kondoh

Biology & Life sciences Pharmacy

Shu Nakao

Ritsumeikan University

Yusuke Kimata

Biology & Life sciences Life Science

Mitsuaki Kashiwagi

Biology & Life sciences Life Science

Takuya Matsumoto

Osaka Prefecture University

Takanori Wakatake

Nara Institute of Science and Technology

Takashi Fukaya

The University of Tokyo

Kenta Maruyama

Aichi Medical University

Tomohisa Hosokawa

Nagoya University

Miharu Maeda

Biology & Life sciences Life Science

Asano Ishikawa

Research Organization of Information and Systems

Keisuke Ikawa

Nagoya University

Kazuki Ide

Hiroshi Miyanishi

University of Miyazaki

Tsuyoshi Hirashima

Kyoto University

Akihiro Goto

Biology & Life sciences Life Science

Taro Fuchikawa

Osaka City University

Kazuya Matsuo

Yuto Takenaka

Ritsumeikan University

Masayuki Morita

Ehime University

Tomomi Wakabayashi

Osaka University

Takahiro Masuda

Yusuke Kobayashi

Hisaaki Hirose

Osaka University

Yuhei Chadani

Okayama University

Takashi Shimada

Biology & Life sciences

Yohei Hayashi

Tohoku University

Toshiyuki Kowada

Biology & Life sciences Life Science

Gosuke Hayashi

Biology & Life sciences Pharmacy

Yoshifumi Yamaguchi

Hokkaido University

InaRIS Fellow

Atsushi Anzai

Biology & Life sciences Medicine

Masayuki Munekane

Kanazawa University

Yuya Sanaki

University of Tsukuba

Chihiro Maeda

Material Science

Wakana Tanaka

The University of Tokyo

Kozue Shiomi

Biology & Life sciences

Kunihiko Morihiro

The University of Tokyo

Satoshi Iwakami

Kyoto University

Yasuo Oguri

Biology & Life sciences Life Science

Keiichiro Suzuki

Osaka University

Akihiko Mougi

Shimane University

Shiho Makino

The University of Tokyo

Misaki Ishibashi

Kyoto University

Yukiko Kimura

National Institutes of Natural Sciences

Masahiro Morimoto

Masanori Nomoto

University of Toyama

Yukiko Kamiya

Akihiro Funamizu

Information Science

Hidefumi Shinohara

Nagoya University

Kenichi Watanabe

Kunio Kondoh

Ayuko Hoshino

The University of Tokyo

InaRIS Fellow

Mizuki Watanabe

Hokkaido University

Tadayoshi Karasawa

Jichi Medical University

Takuya Motooka

Yuka Iwasaki

RIKEN

Hideaki Kato

The University of Tokyo

Kenji Osabe

Tokyo Institute of Technology

Seiji Takashima

Shinshu University

Tsuyoshi Waku

Doshisha University

Yusaku Iwasaki

Shohei Yamamoto

Tokyo Medical and Dental University

Kenji Ikeda

Tokyo Medical and Dental University

Tomomi Tsunematsu

Hokkaido University

Susumu Jitsuki

Biology & Life sciences Life Science

Shohei Nosaki

University of Tsukuba

Eiji Miyauchi

Gunma University

Nobuhiko Yokoshi

Keio University

Hiroyoshi Y. Tanaka

Okayama University

So Nagaoka

Biology & Life sciences Life Science

Takumi Ogawa

Osaka Prefecture University

Daisuke Ino

Osaka University

Takashi Tsuchimatsu

Chiba University

Keita Takahashi

Kuniyasu Saitoh

Koji Atarashi

Yuji Sakai

Tokushima University

Jun-ichi Sakamaki

Juntendo University

Kazuhiko Yamamuro

Kazutoshi Kasho

Biology & Life sciences Life Science

Takashi Tanaka

Shintaro Yamaguchi

Masaki Uchida

Katsuma Hayashi

Kyoto University

Taichi Itoh

Biology & Life sciences

Kazutoshi Iijima

Yokohama National University

Nobuharu Suzuki

Tokyo Medical and Dental University

Chie Aoki-Utsubo

Kobe University

Yosuke Togashi

Biology & Life sciences Medicine

Takeshi Kawabe

Biology & Life sciences Medicine

Seiya Takayanagi

Ayaka Ito

Masashi Kanayama

Tokyo Medical and Dental University

Atsushi Fujimura

Okayama University

Miyako Shiraishi

Osaka University

Hiroshi Nomoto

Takahito Iga

Keio University

Miho Shiratori

Juntendo University

June-Sik Kim

RIKEN

Koichi Murata

Kyoto University

Masaki Takasugi

Osaka Metropolitan University

Koki Katsuhara

Okayama University

Nami Minato

Tetsuya Takano

Kyushu University

Yuichiro Nakata

Chiba University