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Professor, School of Medicine, Aichi Medical University *Profile is at the time of the award.
2024Inamori Research GrantsBiology & Life sciences
I have never thought for a moment that the era will come when the explosion of informatics and computing will make it possible for people to stop being surprised by anything. True science should always be simple, idyllic, and unparalleled, yet many scientists, myself included, have embraced trendy fields for our own research, insisting on the importance of interdisciplinarity, while producing data using the latest methods and producing papers that are nowhere near the level of Renaissance science. I want to be the first to plant my flag in the middle of absolutely nothing, without being restricted to a field or method.
This study demonstrated that single-stranded RNA (ssRNA) contained in extracellular vesicles derived from gut bacteria in feces (FEVs) activates the mechanosensitive ion channel Piezo1 and suppresses the progression of colorectal cancer (CRC). Piezo1 deficiency enhanced tumor formation and Wnt/β-catenin signaling. Furthermore, ursodeoxycholic acid (UDCA) increased the amount of free ssRNA by disrupting FEVs, thereby suppressing high-fat diet–induced CRC.
Kondo T., et al. (2026) Bacterial extracellular vesicle ssRNA prevents colorectal cancer progression via Piezo1 Cell Reports 45, 116737 DOI: 10.1016/j.celrep.2025.116737
Ueda Masashi, Maruyama Kenta (2025) Senso-immunology Stomato-Pharyngology 38, 245-255
Miyamoto S., et al. (2024) Senso-immunology: the hidden relationship between sensory system and immune system Journal of Bone and Mineral Metabolism 42, 413-420 https://doi.org/10.1007/s00774-024-01538-y
Fujikawa M., et al. (2024) Role of Kynurenine and its Derivatives in Neuroimmune System International Journal of Molecular Sciences 25, 7144 DOI: 10.3390/ijms25137144
Kondo T., et al. (2024)Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders European Journal of Cell Biology 103, 151418 https://doi.org/10.1016/j.ejcb.2024.151418
Miyamoto S., et al (2023) Senso-immunology: the past, present, and future The Journal of Biochemistry 174, 305-315 https://doi.org/10.1093/jb/mvad052
Biology & Life sciences
