Shizue Ohsawa

Graduate School of Science, Nagoya UniversityProfessor*Profile is at the time of the award.

2019Inamori Research GrantsBiology & Life sciences

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Research topics: Robust regulation of developmental time axis through “cell-turnover” in Drosophila

Keyword

Summary: The ontogenesis of multi-celled organisms is a process of precise and premeditated formation that takes place in chronological order. It is thought that when the chronology of ontogenesis is distorted as a result of various internal and external disruptions, there is a robust mechanism for correcting the distortions and organizing the formation properly, but this mechanism remains unidentified. Recently, we have discovered that when the development of drosophila larvae is delayed as a result of internal or external disruptions, it induces a type of cell mass behavior in the larvae's primordial wings known as "cell turnover" (cell death and replacement with newly grown cells), which corrects the delay (chronological distortion). The aim of this project is to explicate the molecular basis and role of this previously unknown form of cell mass behavior.

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It is a great honor to be selected for the Inamori Research Grants, which have supported so many outstanding researchers thus far. This grant will encourage me to forge ahead with my research.

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