Aiko Sada

Associate Professor, International Research Center for Medical Sciences (IRCMS), Kumamoto University*Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

Research topics
Elucidating the mechanism of epidermal stem cell formation mediated by commensal bacteria in the neonatal skin
The perinatal period is an important life stage during which the transition from the embryonic to external environment and the maturation of organs occurs. Some diseases, such as atopic dermatitis, are known to develop due to changes in the composition of commensal bacteria during the perinatal period, which affect health throughout life. We have been studying the regulatory mechanisms of epidermal stem cells during skin homeostasis and diseases. In this study, we will explore the mechanisms of skin maturation and epidermal stem cell formation during the perinatal period in response to innate immune signals induced by commensal bacteria.


Using skin stem cells as a model, our research aims to elucidate the mechanisms of skin regeneration, aging, and disease. Our research goal is to reveal the drivers and effectors of stem cell dysfunction. Targeting these factors may prevent or cure diseases at the stem cell level, with implications for applications in regenerative therapy and future treatments of cancer, aging, and other disorders.
In the field of stem cell research, new concepts and cutting-edge technologies are being updated, and interdisciplinary research is also active. This research is also based on collaborative research in a new field, and although there are some difficulties, such as establishing experimental systems, I hope to find some interesting phenomena.

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Biology & Life sciences