Miharu Maeda

Assistant Professor, Graduate School of Medicine, Akita University *Profile is at the time of the award.

2022Inamori Research GrantsBiology & Life sciences

Research topics
Why secretion is inhibited during mitosis?
Many biological factors that function outside or on the surface of cells, such as collagen and hormones, are synthesized inside the cell and then secreted. Although it has become known that secretion is regulated in response to the environment and conditions of the cell, the molecular mechanisms are not fully elucidated. In this study, we will analyze the relationship between the cell cycle and secretion to clarify its physiological significance and to elucidate the pathology of cancer and other diseases and to develop therapeutic methods.


I would like to express my sincere gratitude for the Inamori Research Grant. Based on the support we have received, we will make every effort to further develop this theme.

Outline of Research Achievments

“Secretion” is the process where proteins synthesized in the endoplasmic reticulum (ER) are transported to the outside of the cell, and it ceases during mitosis. We have shown that the binding of Sec16 and TANGO1 is necessary for the formation of ER exit sites (ERES),where proteins are secreted from the ER. We have demonstrated that phosphorylation of TANGO1 leads to the dissociation of ERES during mitosis. In this study, we have newly reported the potential importance of post-translational modification of Sec16 in the formation of ERES.

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Biology & Life sciences