Tomonori Matsumoto

Assistant Professor, Research Institute for Microbial Diseases, Osaka University *Profile is at the time of the award.

2022Inamori Research GrantsBiology & Life sciences

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Research topics: Development of treatment strategy for chemoresistance of cancers by ploidy alterations

Keyword

Summary: Although various kinds of chemotherapeutic agents for cancers have been developed in recent years, cancers inevitably become treatment-resistant and eventually uncontrollable. Therefore, understanding the mechanisms of how cancers become resistant to chemotherapies and developing countermeasures are urgent issues. Cancer cells are known to become polyploid and senescent after chemotherapy, and it is supposed that the ploidy alterations and the escape from senescence play roles in the development of cancer drug resistance. This project aims to elucidate the significance of ploidy alterations and senescence escape in the development of chemotherapy resistance, and to identify novel therapeutic targets that prevent the acquisition of cancer drug resistance.

Message

It is a great honor to be selected for the Inamori Research Grants. I hope to conduct research leading to the development of a novel treatment strategy.

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