Jun-ichi Sakamaki

Associate Professor, Graduate School of Medicine, Juntendo University*Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: Study on the generality, molecular mechanisms, and biological significance of ubiquitination of organellar membrane lipids

Keyword

Summary: Covalent attachment of ubiquitin to proteins is a common post-translational modification involved in various biological processes. It has long been thought that substrates of ubiquitin are restricted to proteins. We have discovered that the ubiquitin protein is covalently conjugated to phospholipids in organellar membranes. However, the molecular mechanism and biological role of phospholipid ubiquitination are unknown. This study aims to understand the underlying molecular basis, biological significance, and its relevance to diseases.

Message

The primary objective of this study is to elucidate the regulatory mechanisms of organellar function, with a particular focus on the unconventional role of ubiquitin as a modifier of membrane lipids.

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