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Assistant Professor, Graduate School of Science, Kyoto University *Profile is at the time of the award.
2024Inamori Research GrantsBiology & Life sciences
Elucidating the molecular mechanisms of gene expression is extremely important for deepening the basic understanding of biology. I would like to make the most of the foundation's funding to conduct basic research that will lead to the elucidation of new life phenomena and their applications.
In this study, we visualized DNA condensate formation by the transcription factor YY1 using a single-molecule DNA curtain assay and revealed that YY1 forms mechanically distinct “soft” and “hard” DNA condensates in a concentration-dependent manner. We further clarified the roles of individual YY1 domains in condensate formation and demonstrated that non-specific DNA interactions facilitate DNA juxtaposition. These findings provide a new mechanistic framework for YY1-mediated enhancer–promoter regulation and chromatin organization. The results were published on bioRxiv and are currently under submission to an international journal.
F Nagae, et al. (2025) Mechanistic models of asymmetric hand-over-hand translocation and nucleosome navigation by CMG helicase Nature Communications 16:10304 https://doi.org/10.1038/s41467-025-65232-x
H Koide, et al. (2025) Solution AFM imaging and coarse-grained molecular modeling of yeast condensin structural variation coupled to the ATP hydrolysis cycle Journal of Molecular Biology 437:169185 https://doi.org/10.1016/j.jmb.2025.169185
F Nagae, et al. (2024) Molecular mechanism of parental H3/H4 recycling at a replication fork Nature Communications 15:9485 https://doi.org/10.1038/s41467-024-53187-4
Biology & Life sciences
