Junichi Kikuta

Associate Professor, Graduate School of Frontier Biosciences, Osaka University*Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

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Research topics: Elucidation of the regulatory mechanisms of osteoclast functions in bone and joint destruction

Keyword

Summary: Osteoclasts are multinucleated giant cells that differentiate from monocyte/macrophage-lineage cells and are responsible for bone resorption. Under physiological conditions, they exist in the bone marrow and play an important role in bone homeostasis by working in concert with osteoblasts, which are responsible for bone formation. On the other hand, in pathological conditions such as arthritis, chronic inflammation at the synovial membrane promote the formation of osteoclasts on the bone surface and induce bone destruction around joints. In this study, by means of intravital imaging techniques, I will clarify the difference between bone resorption under physiological conditions in the bone marrow and pathological bone destruction in the inflammatory joints.

Comment

I am very honored to have been selected for the Inamori Research Grant. I would like to make further efforts toward basic medical research that can be translated to clinical practice.

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