ER and Golgi, are responsible for glycosylation, a universal post-translational modification that occurs on more than 60% of proteins. In this study, we are planning to develop a method to selectively deliver glycan-structure-regulating molecules to the ER or Golgi. Until now, glycans have been regarded as an undruggable target due to the difficulty of their structure regulation. This study is expected to provide the useful tool to change glycan structures, changing glycans into the druggable targets and opening the door to the development of glycoldrug.
