Tomomi Tsunematsu

Lecturer, Faculty of Science, Hokkaido University *Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: Elucidating the mechanisms of neuron-independent sleep/wakefulness regulation

Keyword

Summary: The brain is composed of neurons, glial cells, and others. It is becoming clear that not only neurons but also glial cells play various roles in brain function. Recently, we have revealed that astrocyte activity changes dramatically in mice during the sleep/wakefulness state. In this project, we will examine whether artificially activating astrocytes by chemogenetics can affect sleep/wakefulness state and cortical oscillations, or in other words the causal relationship. This study will elucidate a neuron-independent mechanism of sleep/wakefulness regulation.

Message

We spend a third of our lives asleep, yet we still do not know the answer to "Why do we sleep?" As a sleep researcher, my goal is to unravel the mysteries of sleep.

Outline of Research Achievements

In this study, we used chemogenetic approaches to manipulate astrocyte activity in the mouse brain and examined its effects on sleep/wakefulness regulation. Activation of hippocampal astrocytes increased non-REM sleep and slow-wave activity, whereas activation of pontine astrocytes reduced REM sleep. These findings demonstrate that astrocytes actively and region-specifically regulate sleep/wakefulness states. Our results broaden the current understanding of sleep regulation by highlighting the contribution of astrocytes in addition to neuronal mechanisms.

Kurogi Y, et al. (2024) Chemogenetic activation of astrocytes modulates sleep/wakefulness states in a brain region-dependent manner Sleep Advance 5(1). zpae091 DOI: 10.1093/sleepadvances/zpae091

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