Satoshi Minami

Specially Appointed Assistant Professor (Full time) , Graduate School of Medicine, Osaka University*Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

Research topics
Elucidation of the pathogenesis and therapeutic application for AKI to CKD transition using single cell RNA sequencing analysis
Acute kidney injury (AKI) leads to chronic kidney disease (CKD) (AKI to CKD). The applicant has identified a group of cells in the proximal tubules that do not repair after AKI and atrophy during AKI to CKD, and these cells act on the CKD progression through various intercellular interactions, however, the molecular mechanism underlying these processes are unknown. Recently, single-cell RNAseq analysis has enabled comprehensive analysis of cell differentiation processes, identification of regulatory factors, and cell-cell interactions. In this study, we aim to elucidate the molecular mechanisms underlying the repair and atrophy of proximal tubular cells after AKI and the cell-cell interactions through integrated analysis including single-cell RNAseq analysis, and to apply the findings to the treatment of AKI to CKD.


Traditionally, AKI was thought to be a disease that resolves spontaneously, but in recent years, AKI has been found to be a poor prognosis pathogenesis leading to CKD. Since AKI occurs frequently and there is no treatment for CKD, it is very important to elucidate the pathogenesis of AKI to CKD and to develop a potential treatment. Over the years, I have studied the pathogenesis of AKI to CKD and have shown that proximal tubular cells that have failed to repair become atrophic and induce inflammation and fibrosis via secretion of humoral factors. In this study, we hope to further develop this knowledge by integrative analysis including single cell RNAseq analysis to elucidate the pathogenesis of AKI to CKD and to apply it to treatment.

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Biology & Life sciences