Masayuki Tera

Associate Professor,Graduate school of Technology, Tokyo University of Agriculture and Technology*Profile is at the time of the award.

2020Inamori Research GrantsBiology & Life sciences

Research topics
Development of genetic control system based on nucleic acids higher order structure
G-quadruplex is one of the higher-order structures of DNA and RNA. G-quadruplexes are dynamic structures involved in transcription, translation, and replication in the cells. In this study, small compounds that bind and stabilize G-quadruplex will be designed and synthesized to regulate gene expression.


It is my first time to receive a research grant from the foundation. I would like to produce research results that will support my future research life.

Outline of Research Achievments

In this study, we aimed to analyse the function of a special structure on DNA called the guanine quadruplex (G4). In particular, we developed two new compounds. The first is a compound called 6OTD-Bp, which binds only to specific G4 structures and, when exposed to light, successfully photocrosslinks these structures. The second is a compound called 6LCO, which was found to change the shape of G4 structures. By using 6LCO, we were able to control the interactions between the G4 structures and the proteins that bind to them. In this way, by using these new compounds, we were able to control G4 structures and the proteins that bind to them, leading to promising results for potential applications in controlling gene expression.

Sasaki S, et al. (2023) Regulation of thrombin activity by ligand-induced topological alteration in a thrombin-binding aptamer. Chemical Communications 59, 8862-8865.

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Biology & Life sciences