Hironori Takeda

Assistant professor, Graduate School of Science and Technology, Nara Institute of Science and Technology*Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

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Research topics: Structural study for biological process of membrane protein insertion by the mitochondrial translocator SAM complex

Keyword

mitochondria

Summary: For mitochondria to function normally as energy plant, transport across the outer mitocohndrila outer membrane by β-barrel membrane proteins is essential. The SAM complex inserts these β-barrel membrane proteins into the membrane. In this study, we will elucidate the entire mechanism by which the SAM complex inserts β-barrel membrane proteins into the membrane using a structural biological approach.

Comment

The reaction that inserts a protein into a bilayer is highly complex. A structural biology approach unravels the details of how the SAM complex catalyses such reactions.

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