Akiko Ogawa

Assistant Professor, Institute of Development, Aging and Cancer, Tohoku University *Profile is at the time of the award.

2022Inamori Research GrantsBiology & Life sciences

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Research topics: Regulatory roles of modified RNA metabolism in immunity and disease

Keyword

Summary: Cellular RNA species contain a wide variety of post-transcriptional chemical modifications. About 150 species of RNA modifications have been identified in RNA species from all kingdoms of life. During RNA catabolism, most modified nucleosides are resistant to degradation and are released into the extracellular space. N6-methyladenosine (m6A), widely recognized as an epigenetic mark in RNA, specifically activates human GPCR and acts as a signaling molecule and triggers pathophysiological immune responses, a previously unreported property of RNA modifications. However, the metabolism of m6A which will terminate the m6A-mediated signaling has been unknown. The goal of this research project is to elucidate the regulatory pathway of m6A metabolism.

Message

I would like to pioneer a new nucleic acid physiology from the viewpoint of metabolism of RNA modifications, and through my research, I would like to aim for a radical cure of diseases for which there has been no cure so far.

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