Assistant Professor,Institute of Development, Aging and Cancer, Tohoku University*Profile is at the time of the award.
2020Inamori Research GrantsBiology & Life sciences
I am very honored to be able to promote this research with the grant from the Inamori Foundation. With this encouragement, I will strive for my research every day, aiming to pioneer novel scientific areas.
In this study, we aimed to specify the metabolic pathways that play important roles in germ cells, which are formed during the fetal stage and then differentiate into sperm and eggs through characteristic differentiation in males and females, respectively, and to clarify their roles. In recent years, it has been reported that the increase or decrease in the amount of certain metabolites is involved in the regulation of gene expression and the epigenome (marks attached to DNA and histones that regulate gene expression). Therefore, what kind of metabolic pathways are enhanced or inhibited during germ cell differentiation has been an important issue in the regulation of the process, but many of the changes, especially in fetal germ cells, were unknown. In this study, we analyzed in detail the sex differences in the metabolic state of fetal germ cells, and found that tricarboxylic acid cycle and serine metabolism are enhanced in male germ cells, while pyruvate and fatty acid metabolism are enhanced in female germ cells. As a result of further research, we found that the metabolic pathways of amino acids such as serine, glycine, and methionine are totally enhanced in male germ cells, and that interfering with these pathways changes the differentiation and epigenomic status of male germ cells. On the other hand, pyruvate metabolism, which was enhanced in female germ cells, was found to play an important role in follicle formation through the regulation of gene expression, which was reported in the paper.
Biology & Life sciences