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Assistant Professor, Institutes of Life and Environmental Sciences, University of Tsukuba *Profile is at the time of the award.
2024Inamori Research GrantsBiology & Life sciences
It is an honor to receive research funding from your foundation, and I feel very motivated. I hope to elucidate new aspects of mechanism of signal transduction in plants from my own perspective and contribute to the development of science.
In this study, we investigated the mechanism of target-DNA-dependent higher-order assembly, using droplet formation by the arginine-rich DNA-binding domain of a plant-specific transcription factor as a starting point. We found that amino acid residue X, conserved in a specific clade that acquired major functions in seed plants, is selectively required for large assembly formation without substantially affecting DNA-binding activity. These findings reveal a molecular basis that separates DNA recognition from assembly and provide a foundation for elucidating its biological significance.
Shohei Nosaki, et al. (2025) Single cis-elements in brassinosteroid-induced upregulated genes are insufficient to recruit both redox states of the BIL1/BZR1 DNA-binding domain FEBS Letters vol. 599, pp. 3369–3380 https://doi.org/10.1002/1873-3468.70147
Biology & Life sciences
