Kashiwagi, Mitsuaki

Assistant Professor, International Institute for Integrative Sleep Medicine, University of Tsukuba *Profile is at the time of the award.

2022Inamori Research GrantsBiology & Life sciences

Research topics
Elucidating a glutamatergic neural circuit that induces sleep
Keyword
Summary
Sleep is widely observed across the animal kingdom. Sleep is under the control of homeostasis, suggesting that sleep has vital functions. However, the function and mechanism of sleep remain unclear. Sleep has been thought to be induced by inhibitory neurons by suppressing the neurons crucial for wakefulness partly because drugs that suppress neuronal activity effectively promote sleep.
In this study, we newly generated genetically modified mice in which excitatory neurotransmission is impaired. We found that the amount of sleep in these mice was strongly reduced, suggesting a crucial role of excitatory neurotransmission in the positive regulation of sleep. This study aims to elucidate a novel regulatory mechanism of sleep by clarifying the neural circuits responsible for the short sleep phenotype in this mouse.

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We are very honored to receive a research grant from the renowned Inamori Foundation. We are determined to make a step forward in our sleep research within the term of the grant.

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Biology & Life sciences