Yuichiro Nakata

Assistant Professor, Graduate School of Medicine, Chiba University *Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Study on Heart Failure-Associated Epigenetic Memory Induced by Metabolic Syndrome

Keyword

Summary: With Japan's rapidly aging society, the number of patients with heart failure is increasing. Heart failure imprints a stress memory in hematopoietic stem cells, which contributes to recurrent heart failure. Our goal is to characterize this memory and uncover the mechanisms for its removal, paving the way for the development of novel therapeutic strategies.

Comment

I am deeply honored to have received the Inamori Research Grant. It had been my dream since childhood, so I was truly excited when I received the letter from the foundation.

Outline of Research Achievements

Hematopoietic stem cells derived from obese mice were transplanted, and cardiac function in recipient mice was monitored longitudinally. The recipients did not develop heart failure. These findings suggest that the innate immune memory established in hematopoietic stem cells by metabolic syndrome is insufficient for inducing heart failure through the cardiac macrophages derived from these cells. Next, I investigated the underlying epigenomic regulation of the innate immune memory established in hematopoietic stem cells by heart failure and metabolic syndrome. Distinct histone modification regions were observed.

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