Saori Morino-Koga

Assistant Professor, Institute of Molecular Embryology and Genetics, Kumamoto University *Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

website researchmap

Research topics: In vitro derivation of hematopoietic stem cells from mouse ES cells

Keyword

Summary: Hematopoietic stem cells (HSCs) are the origin of various blood cells and have self-renewal capacity. The establishment of in vitro differentiation methods of HSCs from pluripotent stem cells would be useful for the treatment of various hematological disorders. HSCs are generated from the aorta-gonad mesonephros region during embryogenesis. Therefore, we aim to clarify the developmental process of HSCs in fetal hematopoiesis and to reproduce it in order to create an in vitro culture system.

Comment

I would like to express my heartfelt gratitude for the award of the Inamori Research Grants. My ultimate goal is to provide a new transplant source of hematopoietic stem cells. I will give it my best shot.

Outline of Research Achievments

Hematopoietic stem cells (HSCs) possess the ability to give rise to various blood cell types and have thus been widely utilized in clinical settings through hematopoietic stem cell transplantation. We aim to establish a new source of HSCs by inducing their differentiation from pluripotent stem cells in vitro. In this study, we successfully developed a method to induce HSCs by recapitulating their developmental process using hemogenic endothelial cells, which are precursors of HSCs. This culture system not only serves as a powerful tool for elucidating the mechanisms underlying HSC development, but is also expected to contribute to the future realization of HSC induction from pluripotent stem cells.

S. Morino-Koga et al. (2024) Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells Proc. Natl. Acad. Sci. USA. 121(31) DOI: 10.1073/pnas.2404193121

Find other recipients

Biology & Life sciences

Yu Fukasawa

Tohoku University

Yu Miyamoto

Osaka University

Akihiro Funamizu

Information Science

Takanori Wakatake

Nara Institute of Science and Technology

Atsushi Anzai

Biology & Life sciences Medicine

Chikara Abe

Gifu University

Akiko Kanehara

Masahiko Saito

Material Science

Masayuki Munekane

Kanazawa University

Kunio Kondoh

Hidehisa Kawashima

University of Tsukuba

Tomotaka Ishizaki

Nagoya University

Takuma Kokusho

Kenji Ikeda

Tokyo Medical and Dental University

Yuichiro Nakata

Chiba University

Kotaro Mizuta

Kyoto University

Mizuki Watanabe

Hokkaido University

Yoshiyuki Manabe

Tokai University

Keiichiro Suzuki

Osaka University

Chihiro Maeda

Material Science

Kazuhiko Yamamuro

Takumi Suzuki

Ibaraki University

Junichi Kikuta

University of Tsukuba

Tomoko Okamoto

Hirohisa Ohno

Kyoto University

Misaki Ishibashi

Kyoto University

Miyako Shiraishi

Osaka University

Hidefumi Shinohara

Nagoya University

Noriyoshi Usui

Osaka University

Takashi Iwasaki

Tottori University

Tomoyuki Furuta

Okayama University

Yoshiaki Abe

University of Tsukuba

Ayuko Hoshino

The University of Tokyo

InaRIS Fellow

Takayuki Suzuki

Nagoya University

Jun-ichi Sakamaki

Juntendo University

Masashi Kanayama

Tokyo Medical and Dental University

Masanori Nomoto

University of Toyama

Miho Shiratori

Juntendo University

Tsuyoshi Hirashima

Kyoto University

Nobuhiko Yokoshi

Keio University

Tetsuya Takano

Kyushu University

Takuya Motooka

Kenta Hirami

Daisuke Ono

Biology & Life sciences Life Science

Masashi Mamada

Material Science

Koichi Murata

Kyoto University

Mizuki Endo

Hideaki Morishita

Biology & Life sciences Life Science

Tomonori Nakamura

Kyoto University

Eiji Miyauchi

Gunma University

Susumu Jitsuki

Biology & Life sciences Life Science

Masayuki Tera

Tokyo University of Agriculture and Technology

Yusaku Iwasaki

Tetsuya Kadonosono

Tokyo Institute of Technology

Satoru Morimoto

Keio University

Dana Ulanova

Kochi University

Satoshi Miura

Information Science

Asano Ishikawa

Research Organization of Information and Systems

Daisuke Takimoto

Material Science

Masayuki Morita

Ehime University

Misuzu Hashimoto

Gifu University

Kazutoshi Iijima

Yokohama National University

Shintaro Yamaguchi

Azusa Kondoh

Pharmacy Biology & Life sciences

Tomomi Koshiyama

Ritsumeikan University

Keisuke Ikawa

Nagoya University

Yasuo Oguri

Biology & Life sciences Life Science

Kazunori Kume

Yoshihiro Sakita

Masaki Takasugi

Osaka Metropolitan University

Yoshifumi Yamaguchi

Hokkaido University

InaRIS Fellow

Hideaki Kato

The University of Tokyo

Shintaro Munemasa

Okayama University

Yoshihiro Ujihara

Nagoya Institute of Technology

Yusuke Kimata

Biology & Life sciences Life Science

Rie Wakabayashi

Kyushu University

Yuki Honda

Material Science

Atsushi Saito

Sapporo Medical University

Yuto Takenaka

Ritsumeikan University

Takahito Iga

Keio University

Hiroshi Masai

Material Science

Masaru Hojo

Kwansei Gakuin University

Ayako Gotoh

Konan University

Akihiro Nishiguchi

National Institute for Materials Science

Katsuma Hayashi

Kyoto University

Shu Nakao

Ritsumeikan University

Tsuyoshi Terakawa

Kyoto University

Akiko Ogawa

Biology & Life sciences Life Science

Taichi Noda

The University of Tokyo

Masakazu Hirota

Akihiro Goto

Biology & Life sciences Life Science

Chie Aoki-Utsubo

Kobe University

Nobuharu Suzuki

Tokyo Medical and Dental University

Hidenori Nishio

Nagoya City University

Yuichiro Mishima

Kyoto Sangyo University

Yohei Hayashi

Tohoku University

Takashi Fukaya

The University of Tokyo

Ritsuko Morita

Biology & Life sciences Life Science

Yukiko Kimura

National Institutes of Natural Sciences

Masafumi Kodama

Biology & Life sciences

Akari Fujimoto

Shiho Makino

The University of Tokyo

Satoshi Iwakami

Kyoto University

Hiroshi Suzuki

Nagoya University

InaRIS Fellow

Shizue Ohsawa

Nagoya University

Kunihiko Morihiro

The University of Tokyo

Yuichi Yagita

Kyushu University

Hirofumi Toda

University of Tsukuba

Yusuke Kobayashi

Miu Tamamitsu

The University of Tokyo

Masayuki Sakamoto

Kumamoto University

Ayaka Ito

Kyoko Miura

Kumamoto University

Yuta Hiraike

The University of Tokyo

Takashi Tsuchimatsu

Chiba University

Tomohiro Otsuka

Seiji Takashima

Shinshu University

Gosuke Hayashi

Pharmacy Biology & Life sciences

Yuka Iwasaki

RIKEN

Toshiki Sawada

Material Science

Kenichi Kimura

University of Tokyo

Ryo Ichijo

Kyoto University

Kuniyasu Saitoh

Masaki Uchida

Tomohisa Hosokawa

Nagoya University

So Nagaoka

Biology & Life sciences Life Science

Seiya Takayanagi

Hironori Takeda

Hiroshima University

Keita Takahashi

Jumpei Taguchi

The University of Tokyo

Kenichi Watanabe

Teruhiko Imamura

June-Sik Kim

RIKEN

Yukiko Kamiya

Tomoya Yamaguchi

Kumamoto University

Yuji Sakai

Tokushima University

Minako Ito

Miharu Maeda

Biology & Life sciences Life Science

Mitsuaki Kashiwagi

Biology & Life sciences Life Science

Takashi Shimada

Biology & Life sciences

Takayuki Kuraishi

Kanazawa University

Tomonori Matsumoto

Biology & Life sciences Medicine

Kozue Shiomi

Biology & Life sciences

Wakana Tanaka

The University of Tokyo

Kenta Maruyama

Aichi Medical University

Masahiro Morimoto

Hiroshi Nishimasu

The University of Tokyo

InaRIS Fellow

Takumi Ogawa

Osaka Prefecture University

Kenji Osabe

Tokyo Institute of Technology

Kazuya Matsuo

Kaori Sako

Koki Katsuhara

Okayama University

Kyogo Kobayashi

Kyushu University

Mitsuru Tsuge

Okayama University

Shunsuke Tagami

RIKEN

Toyoaki Natsume

Research Organization of Information and Systems

Koji Atarashi

Kazuki Ide

Yuhei Chadani

Okayama University

Takashi Tanaka

Hiroshi Miyanishi

University of Miyazaki

Taro Fuchikawa

Osaka City University

Takuya Matsumoto

Osaka Prefecture University

Atsushi Fujimura

Okayama University

Satoshi Minami

Osaka University

Takahiro Masuda

Taichi Itoh

Biology & Life sciences

Kazutoshi Kasho

Biology & Life sciences Life Science

Kana Furukawa

Osaka University

Tomomi Wakabayashi

Osaka University

Hiroyoshi Y. Tanaka

Okayama University

Ryohei Thomas Nakano

Hokkaido University

Tadayoshi Karasawa

Jichi Medical University

Shohei Yamamoto

Tokyo Medical and Dental University

Michihito Kono

Masayuki Tsukasaki

The University of Tokyo

Nami Minato

Arisa Hirano

University of Tsukuba

Shun Shibata

Tohoku University

Hisaaki Hirose

Osaka University

Takaaki Ozawa

Osaka University

Hidenori Okamura

Tohoku University

Masato Yamamichi

Research Organization of Information and Systems

Yuma Takahashi

Nara Institute of Science and Technology

Tsuyoshi Waku

Doshisha University

Katsuyoshi Takaoka

Toshiro Moroishi

Yosuke Togashi

Biology & Life sciences Medicine

Ryo Fujimoto

Kobe University

Hitoshi Miyakawa

Utsunomiya University

Shohei Nosaki

University of Tsukuba

Daisuke Ino

Osaka University

Hiroshi Nomoto

Aiko Sada

Okayama University

Ryusuke Hatae

Kyushu University

Takeshi Kawabe

Biology & Life sciences Medicine

Toshiyuki Kowada

Biology & Life sciences Life Science

Kiyoharu Fukushima

Kyoto University

Yuya Sanaki

University of Tsukuba

Akihiko Mougi

Shimane University

Shunsuke Kon

Tokyo University of Science

Tomomi Tsunematsu

Hokkaido University

Makoto Kobayashi