Keisuke Ikawa

Assistant Professor, Graduate School of Science, Nagoya University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

researchmap

Research topics: Elucidation of the Mechanisms underlying Intercellular Interactions Induced by the Heterogeneous Tumor Microenvironment

Keyword

Summary: The cancer microenvironment surrounding oncogenic cells exhibits heterogeneity, which arises and is enhanced through changes in the surrounding environment, such as immune cell accumulation, in addition to genetic changes caused by mutations. However, the full extent of the complex intercellular interactions occurring within this heterogeneous cancer microenvironment and their contributions to cancer progression remain poorly understood. In this study, we aim to elucidate the molecular mechanisms governing tumor growth regulation in a heterogeneous cancer microenvironment by employing spatial transcriptomics to characterize localized intercellular interactions. Furthermore, through genetic analysis and live imaging, we seek to gain deeper insights into the dynamic processes underlying cancer development in this complex microenvironment.

Comment

Using a Drosophila cancer model, our research group has been analyzing cancer growth mechanisms through cell-cell interactions at the in vivo level. Recently we found that macrophages that phagocytose dying malignant tumor cells promote the proliferation of surrounding living malignant tumor cells. The result suggests that local interactions between macrophages and tumor cells, which emerge during tumor progression, induce the activation of multiple cancer-promoting signaling pathways, which propagate throughout the tumor tissue and cause tumor growth. Based on this finding, we aim to comprehensively elucidate local intercellular interactions within the tumor microenvironment by employing spatial transcriptomics, genetic analysis, and live imaging techniques.

Find other recipients

Biology & Life sciences

Yusuke Kimata

Biology & Life sciences Life Science

Toshiro Moroishi

Takashi Tanaka

Masayuki Tera

Tokyo University of Agriculture and Technology

Saori Morino-Koga

The University of Tokyo

Shintaro Yamaguchi

Yusuke Kobayashi

Miho Shiratori

Juntendo University

Yoshihiro Ujihara

Nagoya Institute of Technology

Makoto Kobayashi

Jun-ichi Sakamaki

Juntendo University

Atsushi Anzai

Biology & Life sciences Medicine

Ryo Ichijo

Kyoto University

Takashi Tsuchimatsu

Chiba University

Junichi Kikuta

University of Tsukuba

Taro Fuchikawa

Osaka City University

Kazuhiko Yamamuro

Kazunori Kume

Hiroyoshi Y. Tanaka

Okayama University

Dana Ulanova

Kochi University

Keiichiro Suzuki

Osaka University

Yukiko Kimura

National Institutes of Natural Sciences

Hidenori Nishio

Nagoya City University

Hisaaki Hirose

Osaka University

Hiroshi Nomoto

Toshiki Sawada

Material Science

Masaru Hojo

Kwansei Gakuin University

Mizuki Endo

Tomonori Nakamura

Kyoto University

Kozue Shiomi

Biology & Life sciences

Wakana Tanaka

The University of Tokyo

Daisuke Ono

Biology & Life sciences Life Science

Nobuharu Suzuki

Tokyo Medical and Dental University

Misuzu Hashimoto

Gifu University

Hiroshi Miyanishi

University of Miyazaki

Masashi Kanayama

Tokyo Medical and Dental University

Tetsuya Takano

Kyushu University

Hiroshi Suzuki

Nagoya University

InaRIS Fellow

Kotaro Mizuta

Kyoto University

Kunihiko Morihiro

The University of Tokyo

Tomomi Tsunematsu

Hokkaido University

Kenji Osabe

Tokyo Institute of Technology

Satoru Morimoto

Keio University

Kana Furukawa

Osaka University

Takumi Suzuki

Ibaraki University

Michihito Kono

Yuichi Yagita

Kyushu University

Akihiro Funamizu

Information Science

Tsuyoshi Waku

Doshisha University

Shohei Yamamoto

Tokyo Medical and Dental University

Masayuki Munekane

Kanazawa University

Yusaku Iwasaki

Masato Yamamichi

Research Organization of Information and Systems

Tsuyoshi Hirashima

Kyoto University

Ryusuke Hatae

Kyushu University

Asano Ishikawa

Research Organization of Information and Systems

Gosuke Hayashi

Pharmacy Biology & Life sciences

Shizue Ohsawa

Nagoya University

Hirofumi Toda

University of Tsukuba

Noriyoshi Usui

Osaka University

Masanori Nomoto

University of Toyama

Ritsuko Morita

Biology & Life sciences Life Science

Takeshi Kawabe

Biology & Life sciences Medicine

Satoshi Minami

Osaka University

Mizuki Watanabe

Hokkaido University

Atsushi Fujimura

Okayama University

Kenji Ikeda

Tokyo Medical and Dental University

Toshiyuki Kowada

Biology & Life sciences Life Science

Masafumi Kodama

Biology & Life sciences

Ayuko Hoshino

The University of Tokyo

InaRIS Fellow

Kenichi Watanabe

June-Sik Kim

RIKEN

Takanori Wakatake

Nara Institute of Science and Technology

Yu Miyamoto

Osaka University

Daisuke Takimoto

Material Science

Yuki Honda

Material Science

Keita Takahashi

Satoshi Iwakami

Kyoto University

Shunsuke Kon

Tokyo University of Science

Hidenori Okamura

Tohoku University

Tomohisa Hosokawa

Nagoya University

Yukiko Kamiya

Takashi Fukaya

The University of Tokyo

Ryohei Thomas Nakano

Hokkaido University

Ayako Gotoh

Konan University

Kazuki Ide

Satoshi Miura

Information Science

Chie Aoki-Utsubo

Kobe University

Miyako Shiraishi

Osaka University

Masayuki Morita

Ehime University

Taichi Itoh

Biology & Life sciences

Akihiro Goto

Biology & Life sciences Life Science

Kenta Hirami

Takahito Iga

Keio University

Toyoaki Natsume

Research Organization of Information and Systems

Azusa Kondoh

Biology & Life sciences Pharmacy

Tomomi Koshiyama

Ritsumeikan University

Minako Ito

Kazutoshi Iijima

Yokohama National University

Hideaki Morishita

Biology & Life sciences Life Science

Takashi Shimada

Biology & Life sciences

Aiko Sada

Okayama University

Akiko Ogawa

Biology & Life sciences Life Science

Yoshiyuki Manabe

Tokai University

Yoshihiro Sakita

Susumu Jitsuki

Biology & Life sciences Life Science

Kaori Sako

Yuji Sakai

Tokushima University

Nobuhiko Yokoshi

Keio University

Ayaka Ito

Takayuki Kuraishi

Kanazawa University

Misaki Ishibashi

Kyoto University

Takaaki Ozawa

Osaka University

Taichi Noda

The University of Tokyo

Koki Katsuhara

Okayama University

Yoshifumi Yamaguchi

Hokkaido University

InaRIS Fellow

Tomonori Matsumoto

Biology & Life sciences Medicine

Tomotaka Ishizaki

Nagoya University

Masayuki Tsukasaki

The University of Tokyo

Mitsuru Tsuge

Okayama University

Hironori Takeda

Hiroshima University

Hidehisa Kawashima

University of Tsukuba

Tomomi Wakabayashi

Osaka University

Yuma Takahashi

Nara Institute of Science and Technology

Tetsuya Kadonosono

Tokyo Institute of Technology

Masayuki Sakamoto

Kumamoto University

Akiko Kanehara

Tomoyuki Furuta

Okayama University

Yuka Iwasaki

RIKEN

Takuya Matsumoto

Osaka Prefecture University

So Nagaoka

Biology & Life sciences Life Science

Tomohiro Otsuka

Masaki Takasugi

Osaka Metropolitan University

Seiji Takashima

Shinshu University

Masahiko Saito

Material Science

Yuhei Chadani

Okayama University

Shintaro Munemasa

Okayama University

Takuya Motooka

Akihiro Nishiguchi

National Institute for Materials Science

Arisa Hirano

University of Tsukuba

Takayuki Suzuki

Nagoya University

Hiroshi Nishimasu

The University of Tokyo

InaRIS Fellow

Atsushi Saito

Sapporo Medical University

Takumi Ogawa

Osaka Prefecture University

Hitoshi Miyakawa

Utsunomiya University

Katsuma Hayashi

Kyoto University

Tadayoshi Karasawa

Jichi Medical University

Daisuke Ino

Osaka University

Jumpei Taguchi

The University of Tokyo

Takahiro Masuda

Kenta Maruyama

Aichi Medical University

Mitsuaki Kashiwagi

Biology & Life sciences Life Science

Takuma Kokusho

Koichi Murata

Kyoto University

Hirohisa Ohno

Kyoto University

Teruhiko Imamura

Yohei Hayashi

Tohoku University

Akihiko Mougi

Shimane University

Takashi Iwasaki

Tottori University

Kyogo Kobayashi

Kyushu University

Hideaki Kato

The University of Tokyo

Miharu Maeda

Biology & Life sciences Life Science

Masashi Mamada

Material Science

Kiyoharu Fukushima

Kyoto University

Yuichiro Nakata

Chiba University

Yuta Hiraike

The University of Tokyo

Nami Minato

Kazuya Matsuo

Eiji Miyauchi

Gunma University

Chikara Abe

Gifu University

Miu Tamamitsu

The University of Tokyo

Shu Nakao

Ritsumeikan University

Yuichiro Mishima

Kyoto Sangyo University

Koji Atarashi

Yuya Sanaki

University of Tsukuba

Tsuyoshi Terakawa

Kyoto University

Tomoya Yamaguchi

Kumamoto University

Kenichi Kimura

University of Tokyo

Shohei Nosaki

University of Tsukuba

Seiya Takayanagi

Shiho Makino

The University of Tokyo

Masakazu Hirota

Akari Fujimoto

Yoshiaki Abe

University of Tsukuba

Hidefumi Shinohara

Nagoya University

Tomoko Okamoto

Katsuyoshi Takaoka

Kyoko Miura

Kumamoto University

Hiroshi Masai

Material Science

Kuniyasu Saitoh

Yosuke Togashi

Biology & Life sciences Medicine

Shunsuke Tagami

RIKEN

Masaki Uchida

Yasuo Oguri

Biology & Life sciences Life Science

Shun Shibata

Tohoku University

Rie Wakabayashi

Kyushu University

Kazutoshi Kasho

Biology & Life sciences Life Science

Chihiro Maeda

Material Science

Yu Fukasawa

Tohoku University

Yuto Takenaka

Ritsumeikan University

Ryo Fujimoto

Kobe University

Kunio Kondoh

Masahiro Morimoto