Saori Morino-Koga

Assistant Professor, Institute of Molecular Embryology and Genetics, Kumamoto University *Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

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Research topics: In vitro derivation of hematopoietic stem cells from mouse ES cells

Keyword

Summary: Hematopoietic stem cells (HSCs) are the origin of various blood cells and have self-renewal capacity. The establishment of in vitro differentiation methods of HSCs from pluripotent stem cells would be useful for the treatment of various hematological disorders. HSCs are generated from the aorta-gonad mesonephros region during embryogenesis. Therefore, we aim to clarify the developmental process of HSCs in fetal hematopoiesis and to reproduce it in order to create an in vitro culture system.

Comment

I would like to express my heartfelt gratitude for the award of the Inamori Research Grants. My ultimate goal is to provide a new transplant source of hematopoietic stem cells. I will give it my best shot.

Outline of Research Achievments

Hematopoietic stem cells (HSCs) possess the ability to give rise to various blood cell types and have thus been widely utilized in clinical settings through hematopoietic stem cell transplantation. We aim to establish a new source of HSCs by inducing their differentiation from pluripotent stem cells in vitro. In this study, we successfully developed a method to induce HSCs by recapitulating their developmental process using hemogenic endothelial cells, which are precursors of HSCs. This culture system not only serves as a powerful tool for elucidating the mechanisms underlying HSC development, but is also expected to contribute to the future realization of HSC induction from pluripotent stem cells.

S. Morino-Koga et al. (2024) Transition of signal requirement in hematopoietic stem cell development from hemogenic endothelial cells Proc. Natl. Acad. Sci. USA. 121(31) DOI: 10.1073/pnas.2404193121

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