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About
Research Grants
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Project Associate Professor, Frontier Research and Education Collaboration Square at Tonomachi, Keio University*Profile is at the time of the award.
2025Inamori Research GrantsBiology & Life sciences
This recent selection for the Inamori Research Grants is regarded as a significant step toward elucidating the pathology of ALS and establishing novel therapeutic strategies. ALS is characterized by the loss of both upper and lower motor neurons, and it is very intriguing that differences exist among motor neuron subtypes in terms of the accumulation of abnormally phosphorylated TDP-43 and cell loss. These pathological features serve as important clues for uncovering the molecular mechanisms underlying disease resistance. Moreover, our finding that decreased FOX2B expression in ALS spinal motor neurons contributes to their vulnerability presents a new therapeutic target that has been difficult to address with conventional treatments.
In this study, we will harness iPS cell technology and patient brain/spinal cord samples to conduct detailed analyses of the mechanisms by which specific neurons evade pathology, aiming to develop innovative ALS therapies, including disease-modifying therapy (DMT). With this grant, we will actively incorporate cutting-edge technologies and strengthen our research framework through a multifaceted approach to address the root causes of ALS. In doing so, we aspire to significantly contribute to improving the quality of life for ALS patients and advancing treatment, in close collaboration with domestic and international research partners.
Biology & Life sciences
