Tomotaka Ishizaki

Assistant Professor, Graduate School of Medicine, Nagoya University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Solving Deep Brain Mysteries with Electrodes in the Human Brain: Revealing Physiological Thalamic Neuronal Activity and Abnormal Networks of Epilepsy.

Keyword

Summary: The thalamus plays a crucial role in regulating brain networks, but its neural activity remains difficult to study due to technical limitations. This study utilizes stereoelectroencephalography (SEEG), performed for preoperative evaluation in patients with drug-resistant epilepsy, to directly record thalamic neural activity and analyze its physiological and pathological networks. By elucidating the thalamus's involvement in abnormal epileptic networks, this research is expected to contribute to optimizing the indications and stimulation parameters of deep brain stimulation (DBS). Furthermore, a deeper understanding of thalamic networks may lead to the development of new surgical treatment strategies.

Comment

The neural activity of the human thalamus has long remained unclear. Located at the center of the brain, the thalamus forms networks with numerous brain regions and is known to have complex physiological functions. Understanding thalamic function is akin to uncovering the role of the brain's command center, which could provide valuable insights into the mechanisms of network disorders such as epilepsy.

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