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Assistant Professor, Graduate School of Science, Osaka University *Profile is at the time of the award.
2023Inamori Research GrantsBiology & Life sciences
We want to realize glycoldrug.
Glycosylation is the most ubiquitous post-translational modification and is involved in numerous biological processes. However, because glycans are bio-synthesized in a non-templated process, it is difficult to regulate their structures using genetic approaches, and their functions remain largely unelucidated. In this study, we developed glycan editing methods, aiming to understand and regulate glycan functions. We developed inhibitors of the core fucose biosynthetic enzyme, which plays a critical role in immune regulation. Additionally, we successfully introduced synthetic glycans onto proteins and controlled their dynamics and functions.
Manabe, Y.*; Fukase, K.* et al. (2024) Development of a FUT8 Inhibitor with Cellular Inhibitory Properties Angew. Chem. Int. Ed. Vol.63. e202414682. doi.org/10.1002/anie.202414682
Miura, A.; Manabe Y.* et al. (2024) De Novo Glycan Display on Cell Surfaces Using HaloTag: Visualizing the Effect of the Galectin Lattice on the Lateral Diffusion and Extracellular Vesicle Loading of Glycosylated Membrane Proteins J. Am, Chem. Soc. Vol.146, 22193-22207. doi.org/10.1021/jacs.4c02040
Manabe, Y.*; Fukase, K.* et al. (2023) Improvement of Antibody Activity by Controlling Its Dynamics Using the Glycan–Lectin Interaction Angew. Chem. Int. Ed. Vol.62, e202304779. doi.org/10.1002/anie.202304779
Biology & Life sciences
