Masayuki Tsukasaki

Assistant Professor, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo *Profile is at the time of the award.

2023Inamori Research GrantsBiology & Life sciences

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Research topics: Discovery and regulation of a novel type of bone-forming cell

Keyword

Summary: Bone remodeling is maintained by a balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Osteoblasts play a central role in skeletal homeostasis by creating bone tissues and controlling osteoclastic bone resorption through cytokine production. This study aims to clarify the functional diversity of osteoblasts, which have been considered a single population, and to develop novel strategies against skeletal disease targeting the osteoblast subtypes.

Comment

Work my fingers to the bone to understand the bone!

Outline of Research Achievments

The appropriate shape and size of the skeleton are formed and maintained through the localized activity of skeletal stem cells and their progeny (osteogenic cells). In this study, we aimed to elucidate the functional diversity and heterogeneity of osteogenic cells and focused on a unique population of osteogenic cells residing in the periosteum. We found that periosteal osteogenic cells contribute not only to bone formation but also respond to tumors and promote periosteal thickening, thereby physically impeding tumor progression. This finding not only advances our understanding of the regulatory mechanisms of the skeletal system but also provides in vivo evidence that non-immune systems can respond to tumors and contribute to host defense, shedding new light on tumor–host interactions.

Nakamura, Tsukasaki* et al., (2024) The periosteum provides a stromal defence against cancer invasion into the bone Nature 634(8033):474-481. doi: 10.1038/s41586-024-07822-1

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