Masaki Takasugi

Lecturer, Graduate School of Medicine, Osaka Metropolitan University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Investigation of beneficial and adaptive aspects of aging and their mechanisms

Keyword

Summary: We have previously obtained results suggesting that some of the gene expression changes associated with aging are beneficial from the perspective of an individual’s lifespan, and that comparative biology is a powerful approach for highlighting such adaptive aspects of aging (PMID: 37351606). In this study, based on our unique comparative biological methodology, we aim to establish a framework for distinguishing between the 'positive aspects' and 'negative aspects' of molecular-level aging changes by conducting animal experiments to evaluate the impacts of the aging changes that have been suggested to be adaptive. Our goal is to clarify the nature of 'adaptive aging' and develop methods for its control.

Comment

This study aims to extract the adaptive aspects of aging through an cross-species comparative analysis, which is an unconventional approach. Receiving this grant, I am now more confident and determined to develop this research while valuing its originality. Through this research, I hope to clarify the adaptive aspects of aging and its control methods, ultimately changing the way people perceive aging.

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