Masayuki Munekane

Assistant Professor, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

researchmap

Research topics: Development of antibody drug conjugate labeled with radiolabeled halogen

Keyword

Summary: Antibody-drug conjugates (ADCs) have been attracting attention as biopharmaceuticals that enable cancer cell-specific treatment. However, there are many cases in which sufficient therapeutic effects have not been observed in clinical trials. In this study, we aim to develop ADCs in which DNA-targeting drugs labeled with therapeutic radionuclides are linked to antibodies via stimuli-responsive linkers, and to develop nuclear medicine treatments that achieve high therapeutic effects by achieving both "high accumulation in cancer tissues (cancer cells) by antibodies" and "transfer of radiolabeled compounds released in response to stimuli such as low pH and reducing conditions in cancer cells to the nucleus (DNA)."

Comment

Nuclear medicine therapy is a cancer treatment that utilizes the cytotoxic effects of radiation emitted from radionuclides. Its high therapeutic efficacy has been gaining attention, particularly in cases such as patients with metastatic prostate cancer who have achieved complete remission after receiving a compound bound to an alpha-emitting radionuclide. However, awareness of this treatment remains low, and we aim to develop drugs that will contribute to its widespread adoption.

Find other recipients

Biology & Life sciences

Masashi Mamada

Material Science

Chie Aoki-Utsubo

Kobe University

Kenta Maruyama

Aichi Medical University

Takayuki Kuraishi

Kanazawa University

Yuichiro Nakata

Chiba University

Toshiyuki Kowada

Biology & Life sciences Life Science

Hiroshi Nishimasu

The University of Tokyo

InaRIS Fellow

Yuya Sanaki

University of Tsukuba

Toshiro Moroishi

Hiroshi Nomoto

Yusuke Kimata

Biology & Life sciences Life Science

Rie Wakabayashi

Kyushu University

Masayuki Tera

Tokyo University of Agriculture and Technology

Mizuki Endo

Ryo Fujimoto

Kobe University

Hideaki Kato

The University of Tokyo

Yuta Hiraike

The University of Tokyo

Mizuki Watanabe

Hokkaido University

Takashi Tanaka

Keiichiro Suzuki

Osaka University

Masaru Hojo

Kwansei Gakuin University

Koichi Murata

Kyoto University

Kazuya Matsuo

Shizue Ohsawa

Nagoya University

Hirohisa Ohno

Kyoto University

Miho Shiratori

Juntendo University

Tomonori Nakamura

Kyoto University

Daisuke Ino

Osaka University

Katsuma Hayashi

Kyoto University

Hidenori Nishio

Nagoya City University

Gosuke Hayashi

Pharmacy Biology & Life sciences

Yusuke Kobayashi

Nami Minato

Masahiro Morimoto

Takanori Wakatake

Nara Institute of Science and Technology

Atsushi Anzai

Biology & Life sciences Medicine

Hirofumi Toda

University of Tsukuba

Takaaki Ozawa

Osaka University

Asano Ishikawa

Research Organization of Information and Systems

Kyogo Kobayashi

Kyushu University

Seiji Takashima

Shinshu University

Kenji Osabe

Tokyo Institute of Technology

Takahiro Masuda

Yasuo Oguri

Biology & Life sciences Life Science

Shunsuke Tagami

RIKEN

Takashi Fukaya

The University of Tokyo

Chikara Abe

Gifu University

Kotaro Mizuta

Kyoto University

Takeshi Kawabe

Biology & Life sciences Medicine

Takashi Tsuchimatsu

Chiba University

Akiko Ogawa

Biology & Life sciences Life Science

Mitsuru Tsuge

Okayama University

Kunio Kondoh

Katsuyoshi Takaoka

Takayuki Suzuki

Nagoya University

Yuichi Yagita

Kyushu University

Shintaro Munemasa

Okayama University

Yuhei Chadani

Okayama University

Takashi Iwasaki

Tottori University

Akihiro Nishiguchi

National Institute for Materials Science

Yoshihiro Sakita

Yu Fukasawa

Tohoku University

Shiho Makino

The University of Tokyo

Yosuke Togashi

Biology & Life sciences Medicine

Tomoyuki Furuta

Okayama University

Eiji Miyauchi

Gunma University

Taichi Noda

The University of Tokyo

Seiya Takayanagi

Hisaaki Hirose

Osaka University

Tomomi Tsunematsu

Hokkaido University

Jumpei Taguchi

The University of Tokyo

Hideaki Morishita

Biology & Life sciences Life Science

Masayuki Sakamoto

Kumamoto University

Ryohei Thomas Nakano

Hokkaido University

So Nagaoka

Biology & Life sciences Life Science

Misaki Ishibashi

Kyoto University

Masafumi Kodama

Biology & Life sciences

Shu Nakao

Ritsumeikan University

Ayaka Ito

Kana Furukawa

Osaka University

Kunihiko Morihiro

The University of Tokyo

Jun-ichi Sakamaki

Juntendo University

Masayuki Morita

Ehime University

Tomohisa Hosokawa

Nagoya University

Akiko Kanehara

Miyako Shiraishi

Osaka University

Miharu Maeda

Biology & Life sciences Life Science

Koki Katsuhara

Okayama University

Kenichi Kimura

University of Tokyo

Tomomi Wakabayashi

Osaka University

Tetsuya Kadonosono

Tokyo Institute of Technology

Kazuki Ide

Takuma Kokusho

Ayako Gotoh

Konan University

Takumi Suzuki

Ibaraki University

Hiroshi Miyanishi

University of Miyazaki

Tomotaka Ishizaki

Nagoya University

Yoshihiro Ujihara

Nagoya Institute of Technology

Yusaku Iwasaki

Makoto Kobayashi

Daisuke Ono

Biology & Life sciences Life Science

Takashi Shimada

Biology & Life sciences

Miu Tamamitsu

The University of Tokyo

Ryo Ichijo

Kyoto University

Akari Fujimoto

Shun Shibata

Tohoku University

Taichi Itoh

Biology & Life sciences

Tsuyoshi Waku

Doshisha University

Mitsuaki Kashiwagi

Biology & Life sciences Life Science

Yoshiyuki Manabe

Tokai University

Tetsuya Takano

Kyushu University

Kazuhiko Yamamuro

Chihiro Maeda

Material Science

Masanori Nomoto

University of Toyama

Susumu Jitsuki

Biology & Life sciences Life Science

Kenichi Watanabe

Masahiko Saito

Material Science

Yuka Iwasaki

RIKEN

Masaki Takasugi

Osaka Metropolitan University

Hidefumi Shinohara

Nagoya University

Hitoshi Miyakawa

Utsunomiya University

Yukiko Kamiya

Tomohiro Otsuka

Aiko Sada

Okayama University

Ayuko Hoshino

The University of Tokyo

InaRIS Fellow

Minako Ito

Yuki Honda

Material Science

Yohei Hayashi

Tohoku University

Shohei Yamamoto

Tokyo Medical and Dental University

Keisuke Ikawa

Nagoya University

Keita Takahashi

Ritsuko Morita

Biology & Life sciences Life Science

Satoshi Miura

Information Science

Satoshi Iwakami

Kyoto University

Misuzu Hashimoto

Gifu University

Tsuyoshi Hirashima

Kyoto University

Takahito Iga

Keio University

Masato Yamamichi

Research Organization of Information and Systems

Tadayoshi Karasawa

Jichi Medical University

Akihiro Goto

Biology & Life sciences Life Science

Satoru Morimoto

Keio University

Atsushi Saito

Sapporo Medical University

Kiyoharu Fukushima

Kyoto University

Hiroshi Suzuki

Nagoya University

InaRIS Fellow

Satoshi Minami

Osaka University

Hironori Takeda

Hiroshima University

Shintaro Yamaguchi

Yu Miyamoto

Osaka University

Noriyoshi Usui

Osaka University

Atsushi Fujimura

Okayama University

Kozue Shiomi

Biology & Life sciences

Kazunori Kume

Akihiko Mougi

Shimane University

Kaori Sako

Yuji Sakai

Tokushima University

Takuya Matsumoto

Osaka Prefecture University

Kenji Ikeda

Tokyo Medical and Dental University

Masayuki Tsukasaki

The University of Tokyo

Hiroyoshi Y. Tanaka

Okayama University

Tomomi Koshiyama

Ritsumeikan University

Tomoya Yamaguchi

Kumamoto University

Taro Fuchikawa

Osaka City University

Shunsuke Kon

Tokyo University of Science

Yoshifumi Yamaguchi

Hokkaido University

InaRIS Fellow

Junichi Kikuta

University of Tsukuba

Yoshiaki Abe

University of Tsukuba

Saori Morino-Koga

The University of Tokyo

Hidehisa Kawashima

University of Tsukuba

Daisuke Takimoto

Material Science

Masakazu Hirota

Akihiro Funamizu

Information Science

Yuichiro Mishima

Kyoto Sangyo University

Tomonori Matsumoto

Biology & Life sciences Medicine

Azusa Kondoh

Pharmacy Biology & Life sciences

Kazutoshi Kasho

Biology & Life sciences Life Science

Tomoko Okamoto

Masashi Kanayama

Tokyo Medical and Dental University

Yuto Takenaka

Ritsumeikan University

Tsuyoshi Terakawa

Kyoto University

Teruhiko Imamura

Kuniyasu Saitoh

Shohei Nosaki

University of Tsukuba

Kyoko Miura

Kumamoto University

June-Sik Kim

RIKEN

Toyoaki Natsume

Research Organization of Information and Systems

Toshiki Sawada

Material Science

Yuma Takahashi

Nara Institute of Science and Technology

Arisa Hirano

University of Tsukuba

Masaki Uchida

Hidenori Okamura

Tohoku University

Dana Ulanova

Kochi University

Takumi Ogawa

Osaka Prefecture University

Kazutoshi Iijima

Yokohama National University

Takuya Motooka

Kenta Hirami

Nobuhiko Yokoshi

Keio University

Michihito Kono

Wakana Tanaka

The University of Tokyo

Ryusuke Hatae

Kyushu University

Nobuharu Suzuki

Tokyo Medical and Dental University

Koji Atarashi

Hiroshi Masai

Material Science

Yukiko Kimura

National Institutes of Natural Sciences