Hidenori Okamura

Assistant Professor, Institute of Multidisciplinary Research for Advanced Materials, Tohoku University *Profile is at the time of the award.

2024Inamori Research GrantsBiology & Life sciences

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Research topics: Conception of intracellular photochemical molecular construction and its application to drug activity control

Keyword

Summary: Suppression of side effects is a critical task in drug therapy. In this research, we will explore the new concept of "photo-triggered in vivo synthesis of drug molecules" toward precise control of the pharmacological activity.

Message

I would like to express my deepest gratitude for the support from Inamori Foundation.
With this research grant, I will try my best to explore new photo-chemical approach to control drug activity with high precision.

Outline of Research Achievments

Chemotherapy is a major treatment for cancer and other diseases. However, many of the existing drugs exhibit side effects that significantly reduce the quality of life and prognosis of patients. Thus, there is a strong demand for the development of control systems for pharmacological activity that can reduce side effects. In this study, we have developed a method based on a new mechanism of “construction of molecular skeleton by light” using our originally developed photochemical reaction and succeeded in the proof of concept.

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