Masayuki Munekane

Assistant Professor, Institute of Medical, Pharmaceutical, and Health Sciences, Kanazawa University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

researchmap

Research topics: Development of antibody drug conjugate labeled with radiolabeled halogen

Keyword

Summary: Antibody-drug conjugates (ADCs) have been attracting attention as biopharmaceuticals that enable cancer cell-specific treatment. However, there are many cases in which sufficient therapeutic effects have not been observed in clinical trials. In this study, we aim to develop ADCs in which DNA-targeting drugs labeled with therapeutic radionuclides are linked to antibodies via stimuli-responsive linkers, and to develop nuclear medicine treatments that achieve high therapeutic effects by achieving both "high accumulation in cancer tissues (cancer cells) by antibodies" and "transfer of radiolabeled compounds released in response to stimuli such as low pH and reducing conditions in cancer cells to the nucleus (DNA)."

Comment

Nuclear medicine therapy is a cancer treatment that utilizes the cytotoxic effects of radiation emitted from radionuclides. Its high therapeutic efficacy has been gaining attention, particularly in cases such as patients with metastatic prostate cancer who have achieved complete remission after receiving a compound bound to an alpha-emitting radionuclide. However, awareness of this treatment remains low, and we aim to develop drugs that will contribute to its widespread adoption.

Find other recipients

Biology & Life sciences

Misaki Ishibashi

Kyoto University

Jumpei Taguchi

The University of Tokyo

Tomohiro Otsuka

Seiya Takayanagi

Masakazu Hirota

Tomomi Koshiyama

Ritsumeikan University

Kazuki Ide

Kenta Maruyama

Aichi Medical University

Yusaku Iwasaki

Hirohisa Ohno

Kyoto University

Nami Minato

Takashi Iwasaki

Tottori University

Yoshiyuki Manabe

Tokai University

Yuichi Yagita

Kyushu University

Keiichiro Suzuki

Osaka University

Ryusuke Hatae

Kyushu University

Hiroyoshi Y. Tanaka

Okayama University

Ayako Gotoh

Konan University

Takanori Wakatake

Nara Institute of Science and Technology

Kazuya Matsuo

Satoshi Minami

Osaka University

Wakana Tanaka

The University of Tokyo

Saori Morino-Koga

The University of Tokyo

Keita Takahashi

Masayuki Tera

Tokyo University of Agriculture and Technology

Kazuhiko Yamamuro

Yuji Sakai

Tokushima University

Takayuki Suzuki

Nagoya University

Takumi Suzuki

Ibaraki University

Shohei Nosaki

University of Tsukuba

Masafumi Kodama

Biology & Life sciences

Kenichi Watanabe

Satoshi Miura

Information Science

Kenji Osabe

Tokyo Institute of Technology

Kozue Shiomi

Biology & Life sciences

Kenta Hirami

Yu Miyamoto

Osaka University

Tomohisa Hosokawa

Nagoya University

Takahito Iga

Keio University

Mitsuru Tsuge

Okayama University

Hiroshi Miyanishi

University of Miyazaki

Susumu Jitsuki

Biology & Life sciences Life Science

Eiji Miyauchi

Gunma University

Yusuke Kimata

Biology & Life sciences Life Science

Miu Tamamitsu

The University of Tokyo

Jun-ichi Sakamaki

Juntendo University

Kuniyasu Saitoh

Shintaro Munemasa

Okayama University

Takashi Tanaka

Toyoaki Natsume

Research Organization of Information and Systems

Daisuke Ono

Biology & Life sciences Life Science

Hitoshi Miyakawa

Utsunomiya University

Hidehisa Kawashima

University of Tsukuba

Yusuke Kobayashi

Kunihiko Morihiro

The University of Tokyo

Masashi Mamada

Material Science

Shunsuke Tagami

RIKEN

Masayuki Morita

Ehime University

Gosuke Hayashi

Pharmacy Biology & Life sciences

Kaori Sako

Satoru Morimoto

Keio University

Shiho Makino

The University of Tokyo

Ayaka Ito

Taichi Itoh

Biology & Life sciences

Takaaki Ozawa

Osaka University

Miharu Maeda

Biology & Life sciences Life Science

Satoshi Iwakami

Kyoto University

Kazutoshi Kasho

Biology & Life sciences Life Science

Shun Shibata

Tohoku University

Kazunori Kume

Atsushi Anzai

Biology & Life sciences Medicine

Hirofumi Toda

University of Tsukuba

Arisa Hirano

University of Tsukuba

Yoshifumi Yamaguchi

Hokkaido University

InaRIS Fellow

Nobuhiko Yokoshi

Keio University

Shohei Yamamoto

Tokyo Medical and Dental University

Akihiro Funamizu

Information Science

Azusa Kondoh

Pharmacy Biology & Life sciences

Tomoya Yamaguchi

Kumamoto University

Noriyoshi Usui

Osaka University

Ryo Ichijo

Kyoto University

Masayuki Sakamoto

Kumamoto University

Yuma Takahashi

Nara Institute of Science and Technology

Masaki Uchida

Hiroshi Nomoto

Akihiro Goto

Biology & Life sciences Life Science

Takahiro Masuda

Rie Wakabayashi

Kyushu University

Seiji Takashima

Shinshu University

Atsushi Fujimura

Okayama University

Yukiko Kamiya

Yoshiaki Abe

University of Tsukuba

Mitsuaki Kashiwagi

Biology & Life sciences Life Science

Hisaaki Hirose

Osaka University

Masaki Takasugi

Osaka Metropolitan University

Hironori Takeda

Hiroshima University

Takeshi Kawabe

Biology & Life sciences Medicine

Tsuyoshi Hirashima

Kyoto University

Chikara Abe

Gifu University

Kana Furukawa

Osaka University

Masato Yamamichi

Research Organization of Information and Systems

Katsuma Hayashi

Kyoto University

Mizuki Watanabe

Hokkaido University

Asano Ishikawa

Research Organization of Information and Systems

Chihiro Maeda

Material Science

Shu Nakao

Ritsumeikan University

Kenichi Kimura

University of Tokyo

Aiko Sada

Okayama University

Tomoko Okamoto

Tomotaka Ishizaki

Nagoya University

Yuki Honda

Material Science

Yu Fukasawa

Tohoku University

Takayuki Kuraishi

Kanazawa University

Yuichiro Nakata

Chiba University

Tomoyuki Furuta

Okayama University

Tsuyoshi Terakawa

Kyoto University

Tomonori Matsumoto

Biology & Life sciences Medicine

June-Sik Kim

RIKEN

Takumi Ogawa

Osaka Prefecture University

Michihito Kono

Hideaki Kato

The University of Tokyo

Yohei Hayashi

Tohoku University

Katsuyoshi Takaoka

Yoshihiro Sakita

Daisuke Ino

Osaka University

Akiko Kanehara

Masahiro Morimoto

Minako Ito

Masanori Nomoto

University of Toyama

Ritsuko Morita

Biology & Life sciences Life Science

Yukiko Kimura

National Institutes of Natural Sciences

Koji Atarashi

Chie Aoki-Utsubo

Kobe University

Shunsuke Kon

Tokyo University of Science

Hidefumi Shinohara

Nagoya University

Toshiyuki Kowada

Biology & Life sciences Life Science

Kyogo Kobayashi

Kyushu University

Daisuke Takimoto

Material Science

Tomomi Tsunematsu

Hokkaido University

Tomomi Wakabayashi

Osaka University

Tetsuya Kadonosono

Tokyo Institute of Technology

Kiyoharu Fukushima

Kyoto University

Shizue Ohsawa

Nagoya University

Takashi Tsuchimatsu

Chiba University

Yasuo Oguri

Biology & Life sciences Life Science

Hidenori Okamura

Tohoku University

Yuta Hiraike

The University of Tokyo

Takuma Kokusho

Kotaro Mizuta

Kyoto University

Akiko Ogawa

Biology & Life sciences Life Science

Toshiro Moroishi

Kazutoshi Iijima

Yokohama National University

Masashi Kanayama

Tokyo Medical and Dental University

Yuka Iwasaki

RIKEN

Tadayoshi Karasawa

Jichi Medical University

So Nagaoka

Biology & Life sciences Life Science

Hiroshi Nishimasu

The University of Tokyo

InaRIS Fellow

Takuya Motooka

Ryo Fujimoto

Kobe University

Akihiro Nishiguchi

National Institute for Materials Science

Hiroshi Suzuki

Nagoya University

InaRIS Fellow

Miho Shiratori

Juntendo University

Yuichiro Mishima

Kyoto Sangyo University

Koichi Murata

Kyoto University

Tsuyoshi Waku

Doshisha University

Takashi Shimada

Biology & Life sciences

Akari Fujimoto

Yuya Sanaki

University of Tsukuba

Ryohei Thomas Nakano

Hokkaido University

Kenji Ikeda

Tokyo Medical and Dental University

Ayuko Hoshino

The University of Tokyo

InaRIS Fellow

Junichi Kikuta

University of Tsukuba

Miyako Shiraishi

Osaka University

Takuya Matsumoto

Osaka Prefecture University

Kunio Kondoh

Misuzu Hashimoto

Gifu University

Taichi Noda

The University of Tokyo

Kyoko Miura

Kumamoto University

Mizuki Endo

Hideaki Morishita

Biology & Life sciences Life Science

Keisuke Ikawa

Nagoya University

Shintaro Yamaguchi

Yuto Takenaka

Ritsumeikan University

Dana Ulanova

Kochi University

Masahiko Saito

Material Science

Makoto Kobayashi

Takashi Fukaya

The University of Tokyo

Hidenori Nishio

Nagoya City University

Toshiki Sawada

Material Science

Yoshihiro Ujihara

Nagoya Institute of Technology

Masayuki Tsukasaki

The University of Tokyo

Yuhei Chadani

Okayama University

Masaru Hojo

Kwansei Gakuin University

Atsushi Saito

Sapporo Medical University

Nobuharu Suzuki

Tokyo Medical and Dental University

Yosuke Togashi

Biology & Life sciences Medicine

Tomonori Nakamura

Kyoto University

Teruhiko Imamura

Taro Fuchikawa

Osaka City University

Akihiko Mougi

Shimane University

Tetsuya Takano

Kyushu University

Koki Katsuhara

Okayama University

Hiroshi Masai

Material Science