Yu Miyamoto

Assistant Professor, WPI Immunology Frontier Research Center, Osaka University*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Elucidation of the intrahepatic immunological barrier regulated by macrophages

Keyword

Summary: When the intestinal barrier function is disrupted by diet or aging, various pathogens and antigens, including symbiotic microorganisms in the intestinal lumen, can enter the body in large quantities. The liver immune system plays a crucial role in appropriately processing these invading substances, thereby contributing to the maintenance of homeostasis in both the liver and the entire body. However, if the liver immune system fails to fully process these substances, they will spread throughout the body and trigger various diseases such as diabetes, arthritis, and asthma. Therefore, in this study, I am challenging to elucidate the mechanisms of the liver immune system in detail and develop a medication to enhance its efficiency in processing the invading pathogens and antigens.

Comment

I would like to express my sincere gratitude for being selected for the Inamori Foundation Research Grant. I am committed to advancing my research to gain a deeper understanding of liver immunity, with the aim of contributing to the promotion of healthy life expectancy in humans.

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