Yuya Sanaki

Assistant Professor, Life Science Center for Survival Dynamics, Tsukuba Advanced Research Alliance, University of Tsukuba*Profile is at the time of the award.

2025Inamori Research GrantsBiology & Life sciences

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Research topics: Gut Microbiota Triggers Metabolic Vulnerability in Declining Host

Keyword

Summary: Our bodies maintain a metabolic balance that helps us stay in good shape. However, physiological stresses, such as aging and cancer, can disturb this balance, leading to the wasting of muscle and adipose tissue. Currently, there is no cure for declining physiological function, which means our vitality and survival period can be compromised under stress.
Our research aims to establish effective treatments to fight against physiological stresses. We utilize fruit flies and mice as model organisms to better understand the underlying mechanisms and develop potential interventions.

Comment

In Japanese cliches, "Live bold but short" and "Live thin as noodles but long" express how human life is. However, what is the entity of life's thickness? When you look at individual differences in life, there is a variation that can be called vitality or toughness, but how this affects one's death is not very clear. If we can manipulate the vitality/toughness that directly affects one's life, can our life be Bold and Long?
In this study, we focus on muscle and adipose tissue maintenance under physiological stresses, aiming to enhance your vitality.

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